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. 2017 Aug 30;7:10001. doi: 10.1038/s41598-017-10582-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of serotonin synthesis alleviated postoperative intra-abdominal adhesion formation in mice. The WT mice were pretreated with PCPA and the Tph−/− mice were pretreated 3 days before modelling. Postoperative intra-abdominal adhesion formation was induced by caecum rubbing, and the mice were sacrificed on the 7^th day after the operation to detect the severity of adhesion formation. (A) Representative images of adhesive bands, picrosirius red staining and haematoxylin-eosin staining of adhesive tissues; (B) Representative intra-abdominal adhesion scores based on the Nair, s criteria; (C) Percentage of weight loss, (D) Positive area according to picrosirius red staining; (E) Thickness of the collagen deposition and (F) Inflammation scores were assessed in the adhesive tissues; n = 6, mean ± SEM, ^*P < 0.05 vs. the WT sham group, ^#P < 0.05 vs. the Tph1−/− sham group.