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. 2017 Aug 30;7:10100. doi: 10.1038/s41598-017-10493-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ER-true/TN-like subtype and prognostic signatures. Kaplan-Meier analysis showing survival rates of risk groups defined by prognostic gene signatures and ER-true/TN-like subtypes. (A) 70-gene Signature: Low risk = 586; High risk = 349; p < 0.0001; HR = 3.24 (2.73–4.85). (B) 70-gene Signature and ER-true/TN-like subtypes: Low risk/ER-true = 449; High risk/ER-true = 154; Low risk/TN-like = 137; High risk/TN-like = 195; p < 0.0001. (C) Recurrence Score: Low risk = 472; Intermediate risk = 195; High risk = 268; p < 0.0001. (D) Recurrence Score and ER-true/TN-like subtypes: Low risk/ER-true = 358; Intermediate risk/ER-true = 120; High risk/ER-true = 268; Low risk/TN-like = 125; Intermediate risk/TN-like = 108; High risk/TN-like = 143; p < 0.0001. (E) 8-gene Score: Low risk = 610; High risk = 325; p < 0.0001; HR = 2.61 (2.19–3.94). (F) 8-gene Score and ER-true/TN-like subtypes: Low risk/ER-true = 445; High risk/ER-true = 158; Low risk/TN-like = 165; High risk/TN-like = 167; p < 0.0001.