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. 2017 Aug 30;7:9984. doi: 10.1038/s41598-017-10225-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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hTau KI expression did not lead to any major detrimental phenotypes in Drosophila. (a) The lifespan of hTau KI flies (grey) was comparable to that of both WT (purple) and tau KO (black) control flies (p > 0.05, log-rank test). (b–e) Representative eye pictures of 3-day-old WT (b), tau KO (c) and hTau KI (d) flies, and of 22-day-old hTau KI flies (e). Scale bar: 100 µm. (f–i) Evaluation of photoreceptor degeneration in fly retinas was performed using immunofluorescence against Chaoptin (red) in 3-day-old WT (f), tau KO (g) and hTau KI (h) flies, and in 22-day-old hTau KI flies (i). DAPI was used to stain cell nuclei (blue). Scale bar: 5 µm. (j and k). Electrophysiology recordings in the TTM (j) and DLM (k) were performed in 15- and 34-day-old hTau KI flies and showed no significant difference in neurotransmission through the giant fiber neuronal system between hTau KI flies and WT controls (p > 0.05, Student’s t-test).