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. 2017 Aug 30;7:9984. doi: 10.1038/s41598-017-10225-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mimicking multi-acetylation strikingly altered hTau phosphorylation pattern. Western blot analysis (a) and quantification (b) of hTau phosphorylation (AT8, AT100, anti-pS262-hTau, PHF-1 and Tau1 antibodies) and total hTau levels (polyclonal K9JA antibody) retrieved from head extracts of 2-day-old hTau-wt, hTau-4Q and hTau-4R KI flies. The arrow indicates the specific band for the pS262-hTau western blot. Results were normalised to Tubulin and to total hTau levels and were expressed relative to levels observed in the hTau-wt KI line (*p < 0.05, ***p < 0.001 and ****p < 0.0001, one-way ANOVA followed by Tukey’s post hoc test, n = 5/genotype). Western blots were cropped in this figure. Full blots are shown in Supplementary Figure 18.