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. 2017 Aug 30;7:10049. doi: 10.1038/s41598-017-10365-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High Sorcin expression is a potential prognosticator for HCC clinical outcome after liver resection. (A) A paired representative images for immunohistochemistry (IHC) staining of Sorcin protein in Ts and ANLTs from training and validation cohort. (B) Box-plot analyzed the immunohistochemical scores of Ts and ANLTs from training and validation cohort showed that Ts exhibited higher Sorcin protein expression than corresponding ANLTs. (C) According to IHC immunostaining score, HCC patients dichotomized into high Sorcin expression group (>3) and low Sorcin expression group (≤3). χ² analysis was used to analyze the difference between Ts and ANLTs from training (C1) and validation cohort (C2). (D) Kaplan-Meier analysis of the correlation between Sorcin expression and the disease-free survival (DFS; D1), overall survival (OS; D2), early recurrence (ER; D3) of HCC patients in training cohort. (E) Kaplan-Meier analysis of the correlation between Sorcin expression and the disease-free survival (DFS; E1), overall survival (OS; E2), early recurrence (ER; E3) of HCC patients in validation cohort.