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. 2017 Aug 30;7:10049. doi: 10.1038/s41598-017-10365-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sorcin promotes HCC cell invasion and metastasis in vitro and in vivo. (A&B) Sorcin promoted HCC cell migration and invasion in vitro. Transwell migration (A) and invasion (B) assays of HepG2 cells with Sorcin overexpression (HepG2^Sorcin) or control (HepG2^Vector), and HCCLM3 cells with Sorcin knockdown (HCCLM3^shSorcin) or control (HCCLM3^shcontrol). (C,D) Sorcin promoted HCC cell growth in vivo. (C) Left column: Linear graphs were used to analyze the rate of tumor growth in each group. Middle column: Representative subcutaneous tumors from HepG2^Sorcin and HCCLM3^shSorcin cells and their control cells were shown in the middle panel. Right column: Tumor volumes of each group were shown and compared in the bar charts. (D) Left and middle column: Representative pictures of orthotopic liver exnograft tumors from each indicated groups were shown. Right column: Tumor volumes of each group were shown and compared in the bar charts. (E) Representative pictures of intrahepatic (E1) and lung metastasis (E2). original magnification: left, 100×; right, 400×. (F) The number of metastatic nodules in each mice liver (F1) or lung (F2) was calculated and compared. ***P < 0.001. Error bars, SD.