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. 2017 Aug 30;7:10049. doi: 10.1038/s41598-017-10365-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sorcin activates ERK signaling in HCC. (A) 10-Pathway Reporter Array showed the signaling change in Sorcin-interfered cells. (B) The expression levels of key members of ERK signaling were detected by western blot. (C) Sorcin expression was positively correlated with p-ERK levels in HCC tissues. (C1) Representative IHC images of Sorcin and p-ERK expression in HCC tissues. magnification: 100×. (C2,3) Correlation of Sorcin and p-ERK expression levels was analyzed by Spearman rank correlation test in training (C2) and validation cohort (C3). (D) The migration and invasion assays for HepG2^Sorcin, HCCLM3^shSorcin and their control cells with/without U0126 treatment. ***P < 0.001. Error bars, SD.