Table 2.
The Cox Proportional Hazard Regression Analyses for Disease-free Survival and Overall Survival in Training Cohort.
| Variables | DFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No. | Univariable Analysis | Multivariable Analysis | Univariable Analysis | Multivariable Analysis | |||||
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | ||
| Gender | |||||||||
| Female | 29 | Reference | Reference | ||||||
| Male | 131 | 1.021(0.531–1.963) | 0.346 | NA | 1.081(0.702–1.665) | 0.335 | NA | ||
| Age (years) | |||||||||
| ≤60 | 105 | Reference | Reference | ||||||
| >60 | 55 | 1.124(0.872–1.449) | 0.239 | NA | 1.205(0.752–1.931) | 0.218 | NA | ||
| Serum AFP level(ng/mL) | |||||||||
| ≤20 | 40 | Reference | Reference | ||||||
| >20 | 120 | 1.168(0.634–2.152) | 0.202 | NA | 1.206(0.723–2.012) | 0.283 | NA | ||
| HBsAg | |||||||||
| Negative | 32 | Reference | Reference | ||||||
| Positive | 128 | 1.306(0.910–1.874) | 0.154 | NA | 1.375(0.901–2.098) | 0.171 | NA | ||
| Liver cirrhosis | |||||||||
| Absence | 63 | Reference | Reference | ||||||
| Presence | 97 | 1.288 (0.773–2.146) | 0.251 | NA | 1.136(0.682–1.892) | 0.248 | NA | ||
| Child-Pugh classification | |||||||||
| A | 139 | Reference | Reference | ||||||
| B | 21 | 1.242(0.704–2.360) | 0.195 | NA | 1.247(0.813–1.913) | 0.187 | NA | ||
| Tumor number | |||||||||
| Solitary | 69 | Reference | Reference | Reference | Reference | ||||
| Multiple | 91 | 2.097(1.392–3.159) | 0.006 | 1.841(1.209–2.803) | 0.019 | 2.196(1.809–2.665) | 0.009 | 1.832(1.311–2.560) | 0.034 |
| Tumor size | |||||||||
| ≤5 cm | 58 | Reference | Reference | Reference | |||||
| >5 cm | 102 | 1.316(0.772–1.894) | 0.084 | 1.114(0.628–1.976) | 0.104 | 1.617(0.883–2.308) | 0.132 | NA | |
| Capsular formation | |||||||||
| Presence | 65 | Reference | Reference | Reference | Reference | ||||
| Absence | 95 | 1.957(1.462–2.620) | 0.010 | 1.432(0.908–2.258) | 0.065 | 1.895(1.317–2.727) | 0.017 | 1.361(0.856–2.164) | 0.091 |
| Microvascular invasion | |||||||||
| Absence | 60 | Reference | Reference | Reference | Reference | ||||
| Presence | 100 | 4.135(2.758–6.199) | <0.001 | 2.917(1.809–4.704) | 0.006 | 3.781(2.528–5.655) | <0.001 | 3.015(1.936–4.695) | 0.001 |
| Edmondson-Steiner grade | |||||||||
| Low grade (I and II) | 62 | Reference | Reference | ||||||
| High grade (III and IV) | 98 | 1.077(0.604–1.920) | 0.207 | NA | 1.224(0.815–1.838) | 0.232 | NA | ||
| TNM Stage | |||||||||
| I | 57 | Reference | Reference | Reference | Reference | ||||
| II – III | 103 | 2.634(1.783–3.891) | 0.001 | 2.206(1.501–3.242) | 0.011 | 3.008(1.804–5.016) | 0.002 | 2.273(1.398–3.696) | 0.014 |
| BCLC Stage | |||||||||
| 0-A | 50 | Reference | Reference | Reference | Reference | ||||
| B-C | 110 | 2.163(1.743–2.684) | 0.004 | 1.752(1.419–2.163) | 0.030 | 2.306(1.732–3.074) | 0.005 | 1.904(1.425–2.544) | 0.023 |
| Sorcin expression | |||||||||
| Low | 54 | Reference | Reference | Reference | Reference | ||||
| High | 106 | 3.803(1.894–7.636) | <0.001 | 2.641(1.491–4.678) | 0.008 | 3.934(2.032–7.616) | <0.001 | 2.860(1.836–4.455) | 0.003 |
Abbreviations: NA, not adopt.