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. 2017 Aug 31;37(4):BSR20171089. doi: 10.1042/BSR20171089

Figure 2. Schematic illustration on the role of VEGF-B in trans-endothelial FA transport and angiogenesis.

Figure 2

VEGF-B secreted by cardiocytes, skeletal muscle cells and brown adipose tissue cells signals in a paracrine fashion to the receptors VEGFR1 and NRP1 located on the abluminal membrane of ECs. The binding of VEGF-B to VEGFR1 displays VEGF-A from its VEGFR1 receptor, activates the VEGF-A/VEGFR2 pathway and increases capillary density and tissue perfusion, while stimulation of ECs with VEGF-B up-regulates the expression of vascular FATPs and induces subsequent transport of FAs across the EC layer into tissue cells. Abbreviation: NRP-1, neuropilin 1. Modified from [67]: Hagberg C., Mehlem A., Falkevall A., Muhl L. and Eriksson U. (2013) Endothelial fatty acid transport: role of vascular endothelial growth factor B. Physiology (Bethesda), 28 (2), 125–134)