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. 2017 Aug 30;7:10052. doi: 10.1038/s41598-017-10283-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(S)-Oxiracetam increased the cerebral blood flow in the 2-VO rats. (a) Representative images of the cerebral blood flow. (b) (S)-Oxiracetam increased the cerebral blood flow in the cortex of the 2-VO rats. The scanner head of the laser Doppler was positioned in parallel to the skull at a distance of 15 cm to record the perfusion images. So: (S)-oxiracetam; Ro: (R)-oxiracetam; Rso: oxiracetam. The data are presented as the mean ± SEM, n = 5–6 per group. One-way ANOVA was used to analyze the differences among the groups. ^# P < 0.05, ^## P < 0.01 vs. sham group; *P < 0.05, **P < 0.01 vs. model group.