Table 4.

GO-PCA analysis.

Label	Status	Gene set ID	P-value	Median correlation	Genes
MF: motor activity [5/5]	UP	GO:0003774	0,0000012	0,98	DYNC1I1, KIF3A, KIF3C, KIF5A, KIF5C
CC: microtubule [7/10]	UP	GO:0005874	0,0000073	0,99	KCNAB2, KIF3A, MAPRE3, REEP2, TUBA4A, TUBB2A, TUBB3
BP: glutamate secretion [5/8]	UP	GO:0014047	0,00016	0,96	CPLX1, RAB3A, SLC1A2, SNAP25, STXBP1
BP: cholesterol biosynthetic process [7/10]	UP	GO:0006695	0,000026	0,92	ACLY, CYP51A1, DHCR24, HMGCS1, IDI1, MSMO1, SQLE
CC: axon [10/21]	UP	GO:0030424	0,0001	0,99	CPNE6, EPB41L3, KCNA1, KCNAB2, NEFH, NEFL, NEFM, PTPRN, RAB3A, SCN1B
BP: neg. regulation of viral process [5/8]	DW	GO:0048525	0,0000011	0,43	FBLN1, IFITM1, IFITM2, IFITM3, SLPI
CC: blood microparticle [8/16]	DW	GO:0072562	3,9E-09	0,7	ANGPTL4, APOE, C1QB, C1QC, C3, CP, SERPINA3, STOM
BP: reactive oxygen species metabolic process [6/9]	DW	GO:0072593	0,000013	0,49	CYBA, CYBB, GPX1, GPX3, PDK4, SOD2
BP: receptor-mediated endocytosis [5/17]	DW	GO:0006898	0,00042	0,82	APOE, CD163, FCER1G, ITGB2, MSR1
BP: pos. regulation of inflammatory response [6/10]	DW	GO:0050729	0,00061	0,7	HYAL2, OSMR, S100A9, TLR2, TNFRSF1A, VAMP8

Significant GO signatures detected by GO-PCA tool.