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. 2017 Aug 30;7:9972. doi: 10.1038/s41598-017-10605-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bayesian maximum clade credibility (MCC) phylogeny of H7 gene sequences of waves 1 to 5. Viruses isolated in the Yangtze River Delta, Pearl River Delta, and other regions are highlighted in red, blue, and green, respectively. BEAST tree of H7N9 viruses estimated using HA gene sequences. Orange shadow indicates Clade I of H7N9 viruses; purple represents Clade II. Figure 3A, time of most recent ancestor (TMRCA) of Clade II; Fig. 3B, TMRCA of the entire tree. Figure 3C, TMRCA of Clade I. Figure 3D, TMRCA of the Clade I-A lineage. Figure 3E, TMRCA of the Clade I-B lineage. Figure 3F, TMRCA of the lineage containing H7N9 viruses detected in avian or humans with HP characteristic cleavage site. Purple characters, human HP strains; orange characters, chicken HP strains detected in this study.