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. 2017 Aug 30;7:9968. doi: 10.1038/s41598-017-07442-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Baicalein rescued the rotenone-reduced mitochondrial abundance in SH-SY5Y cells. (a) Representative images of the mitochondrial mass stained by NAO (scale bar: 50 μm). (b) Mean fluorescence intensity was assessed based on the NAO fluorescence on the ArrayScan HCS Reader with the Morphology Explorer BioApplication. (c) mtDNA copy number was determined by real-time qPCR. (d) The expression of PGC-1α, NRF-1, and TFAM, key regulators of mitobiogenesis, was examined by western blotting. (e) The mRNA levels of PGC-1α and its targeted genes (NRF-1, TFAM, ATP5β, cyt-c, COX II, and COX IV) directly involved in mitobiogenesis were detected by RT-qPCR. Values are expressed as the means ± SEMs. N = 3. Statistical analyses were performed using one-way ANOVA. ^##P < 0.01 compared with the control group, ^*P < 0.05, ^**P < 0.01 compared with the model group.