Table 2.
Risk of the Atrial Fibrillation and Thromboembolic Events in Psoriasis Patients by the Severity.
| Outcomes | No. of events | Incidence* | Unadjusted | Multivariable adjusted† | PS-matched | |||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
| Atrial Fibrillation | ||||||||
| Non-psoriasis | 12143/739459 | 1.65 | 1.00 (reference) | — | 1.00 (reference) | — | 1.00 (reference) | — |
| Mild psoriasis | 257/11438 | 2.48 | 1.51 (1.34–1.71) | <0.001 | 1.10 (0.97–1.24) | 0.133 | 1.06 (0.93–1.22) | 0.365 |
| Severe psoriasis‡ | 72/1947 | 4.05 | 2.47 (1.96–3.11) | <0.001 | 1.44 (1.14–1.82) | 0.002 | 1.77 (1.39–2.24) | <0.001 |
| Thromboembolic Events | ||||||||
| Non-psoriasis | 26406/739459 | 3.63 | 1.00 (reference) | — | 1.00 (reference) | — | 1.00 (reference) | — |
| Mild psoriasis | 571/11438 | 5.13 | 1.41 (1.30–1.54) | <0.001 | 1.04 (0.96–1.13) | 0.382 | 0.98 (0.90–1.08) | 0.707 |
| Severe psoriasis | 152/1947 | 8.14 | 2.25 (1.91–2.63) | <0.001 | 1.26 (1.07–1.47) | 0.005 | 1.55 (1.32–1.84) | <0.001 |
*Incidence rates were calculated per 1000 patient-years, within the population who were over 20 years old and not previously diagnosed with atrial fibrillation.
†Multivariable adjusted hazard ratios were calculated by Cox regression models, including age over 65, gender, income level, resident area, hypertension, diabetes, dyslipidemia, congestive heart failure, peripheral arterial disease, prior history of stroke, prior history of myocardial infarction, use of platelet inhibitors, and use of vitamin K antagonists as covariates.
‡Severe psoriasis patients included those with psoriatic arthritis, and those receiving systemic anti-psoriatic treatment, as previously established and validated.
Abbreviations: CI, confidence interval; HR, hazard ratio; PS, propensity score.