Figure 2.

Schematic representation of the JAK-STAT pathway. The cytokine receptor induces activation of JAKs after cytokine stimulation following the phosphorylation of STATs. Furthermore, phosphorylated STATs undergo dimerization and translocate to the nucleus to activate target gene transcription. Genetic aberration in JAKs provoke serious diseases such as PV, ET, PMF as well as cancer.

SOCS, suppressors of cytokine signaling; PI3K, phosphatidyl inositol 3 kinase; Akt, protein kinase B; FOXO, Forkhead box protein O; mTOR, mammalian target of rapamycin.