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. 2017 Aug 30;7:9930. doi: 10.1038/s41598-017-10042-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Cross-sectional scan divided at the posterior boundary of the prelaminar tissue (red dashed line) and anterior lamina cribrosa (LC) surface (green dashed line), from which two projection images were formed. Delineation of the central retinal vessel trunk (CRVT) is marked in each location (red and green circles). (B) Illustration of the three relationships measured: 1) the center of the Bruch membrane opening (BMO) and the LC CRVT (BMO-LC), 2) the BMO center and the prelaminar CRVT (BMO-PL), and 3) the LC CRVT and the prelaminar CRVT (LC-PL). X denotes the centroid of the region (red – prelaminar CRVT centroid, green – LC CRVT centroid, black – BMO centroid). Dashed lines represent the outline of the prelaminar CRVT (red), LC CRVT (green) and BMO margin (black). Blue double-sided arrows indicate the distance measured for the three relationships. (C) Example of the angle measurement (purple) for BMO-LC. X denotes the centroid for the BMO (black) and LC (green).