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. 2017 Aug 30;7:10085. doi: 10.1038/s41598-017-10353-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neurogenesis is severely affected in the SGZ of APP/PS1 mice. (A and B) Western-blot analysis shows a significant decrease (n = 5/genotype/age; ANOVA F(5,22) = 88.33; Tukey’s post hoc p < 0.05) in the level of DCX at 4 and 6 months of age in APP/PS1 mice compared with age-matched WT mice. (C) Light microscopic images of DCX immunolabeling in the dentate gyrus of WT (c1–c3), and APP/PS1 (c4–c6) mice from 2 to 6 months of age. Significant reduction in DCX-positive cells was observed in APP/PS1 mice compared to WT mice during aging; g: granular cell layer; h: hilus. Scale bars: 100 μm (c1–c6).