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. 2017 Aug 30;7:10085. doi: 10.1038/s41598-017-10353-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell proliferation is significantly reduced in the hippocampus of APP/PS1 mice at 6 months of age. (A) Light microscopic images of double immunolabeled cells, BrdU (blue)-DCX (brown), in the DG of 2- and 6-months-old WT (a1 and a2), and APP/PS1 (a3 and a4) mice. (B) The total number of BrdU/DCX-positive cells was significantly reduced in APP/PS1 mice compared to WT mice at 6 months of age (n = 4/age/genotype); ANOVA F(3,11) = 15.57; Tukey’s post hoc test *p < 0.05, ***p < 0.001. Scale bars: 100 μm (a1–a4).