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. 2017 Aug 30;7:10085. doi: 10.1038/s41598-017-10353-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BLBP-positive stem cells in the SGZ in WT and APP/PS1 mice. (A) Light microscopic images of the dentate gyrus of WT (a1–a3) and APP/PS1 (a4–a6) mice immunostained for BLBP. (B) Double confocal images of GFAP (b1–3) and BLBP (b4–6) markers demonstrate the presence of radial glial-like stem cell type-1 progenitors in both WT and APP/PS1 mice as shown in the co-localization images (b7–9). g: granular cell layer; h: hilus; m: molecular cell layer. Scale bars: 25 μm (a1–a6 and b1–b9).