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. 2017 Aug 30;7:10085. doi: 10.1038/s41598-017-10353-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BLBP-positive stem cells are reduced in aging and in APP/PS1 mice. (A) Light microscopic images of the dentate gyrus of WT (a1–a3) and APP/PS1 (a4–a6) mice immunostained for BLBP. (B) Stereological quantification demonstrates an age-depend decrease in BLBP-positive cells (n = 4/genotype/age; ANOVA F(2,8) = 38.93, Tukey’s post hoc test, ***p < 0.001). (C) Stereological quantification shows a significant decrease in the number of BLBP-cells in APP/PS1 mice compared to age-matched WT mice (n = 4/age/genotype; t-test **p < 0.01). Red arrows: BLBP-positive stem cells with broccoli-like cell endings. g: granular cell layer; h: hilus; m: molecular cell layer. Scale bars: 100 μm (a1–a6), 25 μm for inserts.