Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 30;7:10085. doi: 10.1038/s41598-017-10353-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Thin and thick BLBP-positive stem cells are differentially affected in APP/PS1 mice. (A) Representative images of BLBP-positive cells in the dentate gyrus of 6-month-old APP/PS1 mice; radial glia-like stem cells (type-1 cells) display a thin (green arrows) or thick (blue arrows) long radial process that extends from the cell body in the SGZ and traverses the granule cell layer; BLBP-positive non-stem cells exhibit a cell body located out of SGZ and many branched processes (red arrows) resembling mature astrocytes. (B) Stereological quantifications show a significant decrease in the number of BLBP-stem cells extending thin apical process in the APP/PS1 mice compared to WT mice at 6 months of age. However, a significant increase in the number of BLB-stem cells with a thick process is observed in these APP/PS1 mice compared to WT mice (n = 4/genotype/age; ANOVA F(3,12) = 85.545; Tukey’s post hoc test, *p < 0.05, ***p < 0.001). (C) Percentage of thin and thick BLBP-positive stem cells in WT and APP/PS1 at 4- and 6-month-old. g: granular cell layer; h: hilus; m: molecular cell layer. Scale bars: 25 μm.