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. 2017 Aug 30;7:10085. doi: 10.1038/s41598-017-10353-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The microglial population increases in the dentate gyrus of APP/PS1 mice. (A) Double immunofluorescence confocal images for tomato lectin/BrdU (a1–a6) in 6-month-old APP/PS1 mice. The corresponding merged images showed that the BrdU-cells (arrows) observed in the hilus corresponded to microglial cells. (B) Quantitative analysis shows a significant increase of tomato lectin/BrdU double-labeled cells in APP/PS1 mice compared to WT mice (n = 6/genotype; t-test ***p < 0.001). (C) Bv2 proliferation assay shows an increase of proportion of microglia cells in S phase after Aβ treatment. (D) Proliferation index ratio shows a significant increase (showing in the graph) in Bv2 cells treatment with soluble oligomeric Aβ compared to control. Scale bars: 10 μm.