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. 2017 Aug 30;7:10093. doi: 10.1038/s41598-017-10671-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The experimental procedure for localized tumor analysis of TTP is shown, Stromal components (collagen and hyaluronic acid), vascular patency, and verteporfin perfusion. In-vivo measurements of TTP were taken at three planar locations within the pancreatic tumor. The tumor was excised and ex-vivo analysis was conducted to correlate local measurements of TTP with surrounding collagen area fraction, hyaluronic acid area fraction, patent vessel area fraction, and mean fluorescence intensity of verteporfin, in the exact same regionally defined locations.