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. 2017 Aug 30;7:10093. doi: 10.1038/s41598-017-10671-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Texture analysis of collagen distribution was conducted on the tumor images. Entropy (a) and fractal dimensions (b) were compared to TTP in localized ROI’s resulting in R² values of *0.67 and **0.56, respectively. Entropy was correlated with both uniformity (c) (***R² = 0.95; fit: x^−0.25) and fractal dimension (****R² = 0.91) indicating that more heterogeneous distribution of collagen directly results in elevated TTP.