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. 2017 Aug 30;7:10093. doi: 10.1038/s41598-017-10671-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Collagen was enzymatically degraded in AsPC-1 tumors by intratumor injection of Collagenase and pressures pre- and post-administration, were measured, showing a decreased in all tumors studied (a), with a mean TPP reduction of 30%, as compared to the control (change of 0.8%). The individual data is shown before and after as a function of pressure difference (a) and in pre vs. post line plots (b). Verteporfin fluorescence post collagenase was also compared to fluorescence data presented for untreated tumors (c). Residuals between untreated and collagenase treated tumors regression fits were compared as individual data points (d) illustrating a statistically significant increase in verteporfin uptake in collagenase treated tumors.