Table 1.

New loci from analysis of UK Biobank and CARDIoGRAM exome study

UK Biobank								Stage 2 Exome Study		Combined
Lead Variant	Chr	Gene	Description	EA	EAF	OR	P	OR	P	OR	95% CI	P
rs2972146	2	(LOC646736)	intergenic	T	0.65	1.07	0.0011	1.05	2.01×10−7	1.06	1.04–1.07	1.46×10−9
rs12493885 (p.Val29Leu)	3	ARHGEF26	missense	C	0.85	1.07	0.039	1.09	8.28×10−9	1.08	1.06–1.11	1.02×10−9
rs1800449	5	LOX	missense	T	0.17	1.09	0.0039	1.07	1.72×10−7	1.07	1.05–1.09	2.99×10−9
rs11057401 (p.Ser70Cys)	12	CCDC92	missense	T	0.69	1.08	0.001	1.05	4.32×10−7	1.06	1.04–1.08	3.88×10−9

^*Genes for variants that are outside the transcript boundary of the protein-coding gene are shown in parentheses [eg, (LOC646736)].

Chr = Chromosome, CI = Confidence Interval, EA = Effect Allele, EAF = Effect Allele Frequency, OR = Odds Ratio