Figure 4.

AMY-101 Decreases Inflammatory Clinical Parameters of Naturally Occurring Chronic Periodontitis in NHPs after Local Administration Once per Every 2 Weeks

(A–E) AMY-101 was injected (once per every 2 weeks for 6 weeks) into the interdental papillae and the distal gingiva of the third molars of the maxilla (“AMY-101”), whereas the mandible was not treated (“Untreated”). Each animal was clinically examined at the indicated time points and the following clinical parameters were recorded: (A) gingival index, (B) bleeding on probing, (C) probing pocket depth, (D) clinical attachment level, and (E) plaque index. The data are expressed relative to the baseline values (at week 0), set as 100. Results are means ± SD (n = 5 animals). *p < 0.05 and **p < 0.01 compared to baseline (one-way repeated-measures ANOVA and Bonferroni’s multiple-comparisons test).