Figure 6.

Systemic Administration of AMY-101 Improves the Periodontal Condition of NHPs

(A and B) AMY-101 was given systemically by subcutaneous injection every day for 28 days. Clinical examination of (A) probing pocket depth and (B) bleeding on probing was performed at the indicated time points until week 11. The data are expressed relative to the baseline values (at week 0), set as 100. Results are means ± SD (n = 10 animals). *p < 0.05 and **p < 0.01 compared to baseline (one-way repeated-measures ANOVA and Bonferroni’s multiple-comparisons test except for BOP, where the Friedman test was used followed by the Dunn’s multiple-comparisons test due to non-normality of the data).