Figure 1.

NCP modifications in the DNA damage response (DDR) pathway. (a) The structure of a NCP (PDB: 3LZ0) viewed along the DNA axis and the orthogonal direction, coloured according to coulombic surface charge. (b) Representation of two NCPs and linker DNA with critical solvent-exposed DDR modification sites coloured, created in UCSF Chimera. Model based on Xenopus laevis NCP crystal structures (PDB: 1AOI and 3LZ0) and labelled according to human amino acid residues. Disordered tails are indicated by lines and are not to scale. H2AX histone variant is coloured cyan. See text and references [11,12] for a description of the residues modified in the DDR.