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. 2017 Aug 28;372(1731):20160280. doi: 10.1098/rstb.2016.0280

Figure 2.

Figure 2.

Modified histone peptide reader domains in the DDR. Structures of chromatin reader domains referred to in the text, bound to their proposed DDR histone peptide targets. Structures were generated in Pymol or UCSF Chimera. Selected residues and hydrogen-bond/salt bridges are annotated. (a) MDC1 tandem BRCT bound to a Ser-139-phosphorylated H2AX peptide (PDB: 2AZM). (b) MCPH1 tandem BRCT domain with Ser-139-, Tyr-142-phosphorylated H2AX (PDB: 3U3Z). (c) BRD4 bromodomain bound to H4 acetylated Lys-12/16 (PDB: 3UVX). (d) Tandem Tudor domain of 53BP1 bound to a di-methylated H4K20 peptide (PDB: 2LVM). (e) PWWP domain of LEDGF bound to H3 tri-methylated Lys-36 (PDB: 3ZH1). (f) TONSL ankyrin repeat domain bound to an unmodified H4 peptide (PDB: 5JA4).