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53BP1 as a hub of regulation in the DNA damage response. Schematic representation of 53BP1 overlaid with known structures. Shown is the cryo-electron microscopy density for 53BP1 and ubiquitin (EMDB-8246) overlaid on the X. laevis NCP crystal structure (PDB: 3LZ0), and the crystal structure of the 53BP1 C-terminal tandem BRCT repeat domain bound to a γ-H2AX peptide (dashed grey line). Inhibitory modules referred to in the text are annotated.
