Figure 7. VEGF levels in the hippocampus in response to an acute exercise bout on the treadmill.

VEGF^f/f and VEGF^HSA−/− mice were subjected to a 1 h exercise session on the treadmill. The VEGF^f/f mice could easily maintain a speed of 33 cm s⁻¹ for 1 h. The VEGF^HSA−/− mice had trouble completing the test. An additional group of VEGF^f/f mice were run at a higher speed of 40 cm s⁻¹ (approximately 60% of the average maximal speed for this group). VEGF levels were measured in the hippocampus dissected 1 h after the exercise session. Data are expressed as the mean ± SEM, n = 6–14. ^*Difference between VEGF^f/f mice run at 40 cm s⁻¹ and the VEGF^f/f rest group, P < 0.05.