Table 3.
Changes in physiological parameters in newborn lambs with positive or negative contralateral ΔoxyHb response, following median nerve stimulation for 1.8, 4.8 or 7.8 s (values are means ± SEM; individual values are shown where n < 3 available)
| 1.8 sa | 4.8 s | 7.8 s | |||||
|---|---|---|---|---|---|---|---|
| Negative (n = 2) | Positive (n = 3) | Negative (n = 5) | Positive (n = 3) | Negative (n = 3) | Positive (n = 5) | ||
| MABP | Time to peak (s) | 5.0, 4.0 | 7.6 ± 0.7 | 8.2 ± 1.3 | 7.0 ± 1.0 | 10.0 ± 3.5 | 9.0 ± 0.3 |
| Peak amplitude (mmHg) | 0.5, 1.5 | 1.7 ± 0.5 | 0.0 ± 0.8 | 4.2 ± 1.0† | −0.5 ± 1.1 | 5.0 ± 1.0* | |
| Contralateral ΔoxyHb | Time to peak/nadir (s) | 12.0, 3.0 | 9.3 ± 1.8 | 14.8 ± 1.4 | 8.7 ± 1.5‡ | 17.7 ± 2.3 | 10.6 ± 2.5* |
| Peak/nadir amplitude (μm cm) | −3.2, −5.3 | 3.5 ± 0.9 | −7.5 ± 0.9 | 9.2 ± 3.7* | −12.1 ± 3.9 | 8.9 ± 2.0* | |
| Ipsilateral ΔoxyHb | Time to peak/nadir (s) | 11.0, 3.0 | 9.3 ± 0.3 | 14.2 ± 2.8 | 8.3 ± 0.9 | 17.3 ± 2.6 | 9.8 ± 0.6* |
| Peak/nadir amplitude (μm cm) | −2.1, −3.3 | 4.4 ± 1.2 | −5.2 ± 1.9 | 10.3 ± 3.1* | −10.7 ± 3.6 | 10.6 ± 2.5 | |
| LDF | Time to peak (s) | 9.0 | 11.0 | 5.0 | 8.0, 6.0 | NA | 9.0 ± 0.3b |
| Peak amplitude (BPU) | 32.8 | 15.5 | 139.4 | 1.0, 2.1 | NA | 62.6 ± 31.4b | |
aWith 1.8 s stimulation, no response was obtained in 3 out of 8 lambs. b n = 3 available. † P = 0.07 vs. negative pattern; ‡ P = 0.07 vs. negative pattern; * P < 0.05 vs. Negative pattern. BPU, blood perfusion unit; ΔoxyHb, changes in oxyhaemoglobin; LDF, laser Doppler flowmetry; MABP, mean arterial blood pressure; NA, not available.