Table 2.
Fecal excretion of DON and DON sulfonate metabolites profiles differs by sex.
| % Cumulative DON Dose | ||||||||
|---|---|---|---|---|---|---|---|---|
| Time | 2 h | 4 h | 8 h | 12 h | ||||
| Sex | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ |
| DON | 1.10 ± 0.24 | 0.68 ± 0.29 | 1.90 ± 0.41 | 1.00 ± 0.35 * | 2.32 ± 0.45 | 1.15 ± 0.36 * | 2.48 ± 0.49 | 1.21 ± 0.37 * |
| DON S1 | 0.04 ± 0.01 | 0.02 ± 0.01 | 0.29 ± 0.07 | 0.19 ± 0.03 | 0.62 ± 0.05 | 0.38 ± 0.03 * | 0.85 ± 0.08 | 0.47 ± 0.02 * |
| DON S2 | 0.16 ± 0.05 | 0.05 ± 0.02 * | 1.56 ± 0.43 | 0.73 ± 0.15 | 3.46 ± 0.40 | 1.51 ± 0.15 * | 4.93 ± 0.57 | 1.93 ± 0.16 * |
| DON S3 | 0.03 ± 0.01 | 0.01 ± 0.01 | 0.22 ± 0.09 | 0.13 ± 0.03 | 0.29 ± 0.10 | 0.15 ± 0.03 | 0.35 ± 0.04 | 0.17 ± 0.03 |
| Total | 1.34 ± 0.21 | 0.75 ± 0.31 | 3.93 ± 0.84 | 2.12 ± 0.43 | 6.70 ± 0.86 | 3.32 ± 0.44 | 8.30 ± 1.05 | 4.05 ± 0.43 |
DON (1 mg/kg bw) was administered i.p. to mice. Feces was collected over 24 h and analyzed by LC–MS/MS. Data are mean ± SEM (n = 8). Asterisk indicates significance from male at time point (p < 0.05).