Table 4.
Comparison of DON and DON metabolite concentrations in kidney by sex.
| Concentration (nmol/g) | ||||||
|---|---|---|---|---|---|---|
| Time | 1 h | 2 h | 4 h | |||
| Sex | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ |
| DON | 2.09 ± 0.14 | 1.76 ± 0.16 | 0.63 ± 0.08 | 0.59 ± 0.05 | 0.16± 0.01 | 0.09 ± 0.01 * |
| DON-3-GlcA | 2.86 ± 0.31 | 0.98 ± 0.09 * | 0.99 ± 0.12 | 0.33 ± 0.04 * | 0.17 ± 0.04 | 0.06 ± 0.01 * |
| DON-8,15-hk-8-GlcA | 2.33 ± 0.27 | 0.74 ± 0.03 * | 0.93 ± 0.11 | 0.21 ± 0.02 * | 0.15 ± 0.05 | 0.05 ± 0.01 |
| iso-DON-8-GlcA | 0.43 ± 0.04 | 0.08 ± 0.02 * | 0.19 ± 0.02 | 0.02 ± 0.01 * | 0.06 ± 0.02 | ND |
DON (1 mg/kg/bw) was administered i.p. to mice. Tissues were collected over 4 h and analyzed by LC–MS/MS. Data are mean ± SEM (n = 8); ND = not detected. Asterisk indicates significance from male at time point (p < 0.05).