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. 2017 Jul 26;15(8):236. doi: 10.3390/md15080236

Figure 3.

Figure 3

Effect of COS conjugation on PCV2-specific antibody production of IgG, IgG isotypes and IgM in mouse serum. Mice were intramuscularly injected with PBS, PCV2, NACOS-PCV2, LCOS-PCV2, HCOS-PCV2 or ISA206/PCV2 mixture on day 0, 14 and 28. The blood samples were collected at day 14, 28 and 42 dpi. The antibody titers of IgG (a); IgG1 (b); IgG2a (c); IgG2b (d); IgG3 (e) and IgM (f) were determined by ELISA, respectively. Data are represented as means ± SD (n = 6) of duplicate wells. * p < 0.05 or ** p < 0.01, compared to the PCV2 group.