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Sinulariolide suppressed MMP-2/-9 and urokinase protein expressions, and augmented tissue inhibitor of metalloproteinases (TIMP)-1/-2 protein expressions. Total cell lysates from TSGH-8301 cells treated with sinulariolide were analyzed in terms of their expression levels of MMP-2, MMP-9, urokinase, and TIMP-1/-2 by Western blotting. C: cells treated with DMSO vehicle only. β-actin was used as the protein loading control.
