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5-Hydroxycyclopenicillone (1) significantly decreases the formation of Aβ1-42 fibrils. Aβ1-42 monomers (10 μM) were incubated with or without 1 or curcumin at indicated concentrations for 3 days. Aβ fibrils were measured using the thioflavin T (ThT) assay. ** p < 0.01 vs. Aβ1-42 group (ANOVA and Dunnett’s test).
