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Serial PET imaging of 89Zr-DFO-AMG102 in positive (U87MG HGF+, MET+) and negative (MKN45 HGF−, MET+) mouse xenografts (∼30 μg, ∼4.8–5.6 MBq [∼130–150 μCi], 200 μL of sterile saline), showing selective and high uptake in tumors that possess high local HGF protein levels (U87MG, ∼40 %ID/g) and low uptake in tumors with low HGF levels (MKN45, ∼5–10 %ID/g, EPR uptake only). Max = maximum; Min = minimum.
