Table 3.

Univariable and multivariable predictors of CD4 count change during transition to adult care

	Univariablec			Multivariable (n = 262b)
Predictor	Coefficient	95% CI	p value	Coefficient	95% CI	p value
Constant				154.0	65.6, 242.5	0.001
Main effects:a
Time before transition (per 1 year before transition)	9.2	1.7, 16.8	0.016	2.5	−9.5, 14.5	0.681
Time after transition (per 1 year after transition)	−2.3	−12.7, 8.0	0.658	−19.6	−33.8, −5.4	0.007
Female	−19.2	−72.4, 34.0	0.479	−41.1	−84.5, 2.3	0.064
Non-black ethnicity	−80.6	−146.7, −14.4	0.017	29.7	−26.2, 85.6	0.298
Born abroad	−3.5	−58.5, 51.6	0.902	−0.5	−43.7, 42.8	0.983
Year of birth (per 1 year increase)	20.0	11.5, 28.5	<0.001	13.7	6.7, 20.8	<0.001
Nadir CD4 cell count (per 10 cells/mm3 increase)	7.8	6.4, 9.3	<0.001	5.9	4.3, 7.4	<0.001
Viral suppression (time updated)
Non-suppressed, ≥400 copies/mL	0.0			0.0
Suppressed, <400 copies/mL	131.6	122.4, 140.7		134.5	125.2, 143.8
Missing	58.9	15.6, 102.3	<0.001	60.6	16.2, 105.1	<0.001
Interactions with time before transition (per 1 year):
Nadir CD4 cell count (cells/mm3)
0–99	-			0.0
100–199				10.1	−5.5, 25.5
200–299				12.5	−2.9, 27.9
300+				27.7	9.0, 46.4	0.038
Interactions with time after transition (per 1 year):
Female				24.0	6.0, 41.9	0.009
Non-black ethnicity				34.1	11.6, 56.6	0.003

CI, confidence interval

^aMain effects can be considered in isolation (i.e. ignoring interactions) when all other variables are equal to 0 (continuous) and notably at transition or equal to the baseline category (categorical).

^bNumber of participants.

^cUnivariable models number of participants, n = 271 except for non-black ethnicity (n = 266), born abroad (n = 266), nadir CD4 cell count (n = 269).