Table 1.
Study [Ref] (Region) | Population | Median age at Transfer (years) | Post-HCT Retention | Post-HCT cART Adherence |
Post-HCT HIV Suppression |
Post-HCT CD4 Change |
Post-HCT Mortality |
---|---|---|---|---|---|---|---|
Maturo, 2015 [17] (US) | N=38 BA-HIV | NA | 18 (47%) completed transfer to adult careb | NA | NA | NA | NA |
Fish, 2014 [60] (UK) | N=14, PA-HIV | 17 | NA | At transfer: 64% taking HAART At death: 36% taking HAART |
14% with documented suppression at last evaluation | At transfer: median CD4: 120 cells/uL At death: median CD4: 27 cells/uL |
100% (by study design) |
Ryscavage, 2016 [42] (US) | N=50 19 PA-HIV 31-BA-HIV |
24.5 | 50%a | NA | Pre-transfer: 36% Post-transfer: 57% (p=NS) |
Pre-transfer: 347 cells/uL Post-transfer: 351 cells/uL |
0% |
Hope, 2016 [61] (UK) | N=211 PA-HIV | 17.6 | 88% | NA | Pre-transfer: 43% Post-transfer: 63% (p=<.001) |
Pre-transfer: 450 cells/uL Post-transfer: 420 cells/uL *Rate of decline decreased post transfer |
4.3% |
Righetti, 2015 [62] (Italy) |
N=45 | 8.8 | 84%b | NA | Post-transfer: 73% | NA | NA |
Kakkar, 2016 [59] (Canada) | N=45 PA-HIV (25 consented to study) |
18 | 76%c | 60% reported less than “excellent” adherence | Pre-transfer: 60% | Pre-transfer: CD4>500 cells/uL: 41%Post-transfer: CD4>500 cells/uL: 29% | 8.9% |
Weijsenfeld, 2016 [11] (Netherlands) |
N=59 78% PA-HIV 7% BA-HIV 12% unknown |
18.8 | 86% Mean missed appts increased from 0.2/yr to 0.3/yr after HCT (p<.001) |
NA | NA | NA | NA |
Westling, 2016 [10] (Sweden) |
34 91% PA-HIV |
19 | NA | Pre-transfer: 88% prescribed HAART | Pre-transfer: 90% Post-transfer: 92% |
NA | NA |
PA-HIV: perinatally-acquired HIV; BA-HIV: behaviorally acquired HIV; HAART: Highly active antiretroviral therapy; HCT: health care transition
aRetention was defined as the completion of at least two visits over 12 months following linkage to adult care.
bDefinition of post-HCT not defined.
cRetention was defined as at least one physician visit within 6 months of the interview.