Table 2.
Univariate and multivariate logistic regression analyses of variables associated with risk of T2DM in PWS
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value* | OR (95% CI) | P-value* | |
| Age (>18 years) | 6.81 (2.51–18.47) | <.001 | 1.87 (0.47–7.47) | 0.373 |
| Gender (male) | 0.38 (0.14–1.04) | 0.060 | 0.60 (0.16–2.28) | 0.455 |
| Genotype (deletion) | 0.85 (0.30–2.40) | 0.756 | - | - |
| Obesitya (BMI > 2SD or >30 kg/m2) | 5.75 (2.02–16.40) | 0.001 | 6.76 (2.10–21.70) | 0.001 |
| HOMA-IR | 1.31 (1.09–1.59) | 0.005 | 1.73 (1.31–2.29) | <.001 |
| Dyslipidemia (yes) | 4.92 (1.84–13.20) | 0.002 | 1.55 (0.38–6.33) | 0.545 |
| GHT (yes) | 0.39 (0.11–1.37) | 0.141 | - | - |
| Age at GHT start (years) | 1.02 (0.90–1.15) | 0.792 | - | - |
| Duration of GHT (≥7.2 years) | 0.75 (0.27–2.07) | 0.572 | - | - |
| Hypogonadism (yes) | 3.33 (1.30–8.53) | 0.012 | 2.15 (0.61–7.63) | 0.237 |
| Central precocious puberty (yes) | 0.27 (0.06–1.28) | 0.10 | - | - |
Variables with p < 0.10 were included in a multivariate logistic regression with conditional backward selection model
Abbreviations: T2DM type 2 Diabetes Mellitus, PWS Prader-Willi syndrome, OR odds ratio, CI confidence interval, GHT growth hormone treatment, HOMA-IR homeostasis model assessment, BMI body mass index
*Significant association was classified as p < 0.05
aObesity is defined as BMI cut-off point >30 in adults, >2 SDS in children and adolescents