Table 1.
Overall survival of MDS patients with different miR-124 methylation levels at CpG sites by pyrosequencing
| mir-124 genes | Cut-off values (%) | No. of patients | Overall survival (months) | P | ||
|---|---|---|---|---|---|---|
| Low-meth | High-meth | Low-meth | High-meth | |||
| miR-124-1 | 4.9 | 33 | 23 | 31.8 | 8.4 | 0.025 |
| miR-124-1-1 | 3.5 | 15 | 41 | 32.7 | 11.6 | 0.034 |
| miR-124-1-2 | 4.5 | 15 | 41 | 32.7 | 11.3 | 0.048 |
| miR-124-1-3 | 3.5 | 16 | 40 | 21.8 | 11.6 | 0.209 |
| miR-124-1-4 | 8.5 | 44 | 12 | 21.8 | 5.4 | <0.001 |
| miR-124-2 | 24.8 | 27 | 29 | 31.8 | 6.6 | 0.004 |
| miR-124-2-1 | 11.5 | 23 | 33 | 31.8 | 11.3 | 0.125 |
| miR-124-2-2 | 15 | 26 | 30 | 31.8 | 6.6 | 0.020 |
| miR-124-2-3 | 19.5 | 35 | 21 | 21.8 | 6.6 | 0.053 |
| miR-124-2-4 | 16.5 | 35 | 21 | 31.8 | 6.2 | 0.001 |
| miR-124-2-5 | 30 | 24 | 32 | 32.7 | 6.6 | 0.001 |
| miR-124-3 | 8.6 | 21 | 35 | 32.7 | 7.6 | 0.010 |
| miR-124-3-1 | 6.5 | 15 | 41 | 31.8 | 12.8 | 0.117 |
| miR-124-3-2 | 10.5 | 29 | 27 | 31.8 | 6.6 | 0.052 |
| miR-124-3-3 | 4.5 | 17 | 39 | 23.8 | 7.7 | 0.306 |
| miR-124-3-4 | 14.5 | 19 | 37 | 31.8 | 11.6 | 0.094 |
| miR-124-3-5 | 12 | 37 | 19 | 31.8 | 6.6 | 0.004 |
| miR-124-3-6 | 4.5 | 20 | 36 | 31.8 | 7.5 | 0.009 |
| miR-124-3-7 | 6.5 | 20 | 36 | 31.8 | 11.3 | 0.048 |
| miR-124-3-8 | 11.5 | 19 | 37 | 46.5 | 7.5 | <0.001 |
| miR-124-3-9 | 8.5 | 36 | 20 | 31.8 | 6.6 | 0.026 |
Italics are statistically significant