Table 2.
Leukaemia-free survival of MDS patients with different miR-124 methylation levels at CpG sites by pyrosequencing
| mir-124 genes | Cut-off values (%) | No. of patients | Leukaemia-free survival (months) | P | ||
|---|---|---|---|---|---|---|
| Low-meth | High-meth | Low-meth | High-meth | |||
| miR-124-1 | 7.4 | 43 | 13 | 36.3 | 12.3 | 0.029 |
| miR-124-1-1 | 3.5 | 15 | 41 | 36.9 | 31.9 | 0.379 |
| miR-124-1-2 | 4.5 | 15 | 41 | 40.6 | 25.2 | 0.148 |
| miR-124-1-3 | 3.5 | 16 | 40 | 34.9 | 33.1 | 0.688 |
| miR-124-1-4 | 8.5 | 44 | 12 | 36.6 | 5.5 | 0.010 |
| miR-124-2 | 24.8 | 27 | 29 | 43.1 | 18.0 | 0.001 |
| miR-124-2-1 | 11.5 | 23 | 33 | 40.3 | 23.5 | 0.058 |
| miR-124-2-2 | 15 | 26 | 30 | 42.9 | 18.3 | 0.002 |
| miR-124-2-3 | 19.5 | 35 | 21 | 37.2 | 18.0 | 0.083 |
| miR-124-2-4 | 16.5 | 35 | 21 | 38.2 | 18.4 | 0.011 |
| miR-124-2-5 | 30 | 24 | 32 | 44.7 | 18.0 | 0.001 |
| miR-124-3 | 8.6 | 21 | 35 | 39.5 | 24.1 | 0.069 |
| miR-124-3-1 | 13.5 | 42 | 14 | 35.2 | 12.5 | 0.271 |
| miR-124-3-2 | 10.5 | 29 | 27 | 36.5 | 24.2 | 0.178 |
| miR-124-3-3 | 4.5 | 17 | 39 | 32.1 | 30.1 | 0.302 |
| miR-124-3-4 | 14.5 | 19 | 37 | 34.4 | 19.2 | 0.042 |
| miR-124-3-5 | 9.0 | 31 | 25 | 36.9 | 24.0 | 0.119 |
| miR-124-3-6 | 4.5 | 20 | 36 | 39.1 | 30.4 | 0.096 |
| miR-124-3-7 | 7.5 | 29 | 27 | 36.4 | 30.8 | 0.279 |
| miR-124-3-8 | 11.5 | 19 | 37 | 44.3 | 21.7 | 0.005 |
| miR-124-3-9 | 8.5 | 36 | 20 | 35.6 | 21.0 | 0.254 |
Italics are statistically significant