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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Metabolism. 2017 Jun 21;74:32–40. doi: 10.1016/j.metabol.2017.06.006

Figure 2. XO inhibition reduces the levels of ROS and XO activity and decreases plasma uric acid levels induced by WD.

Figure 2

A. Representative images for quantification of 3-nitrotyrosine by immunostaining. B–D. The bar graph showing increased oxidative stress in EC (B), VSMC (C) and adventitial layer (D) of aorta and its prevention by XO inhibition. E. XO activity in aortic tissue was significantly increased in WD group but not in WD plus XO inhibitor group. N = 3 to 6 per group. CD - control diet, WD - Western Diet, WDA - Western diet plus allopurinol. Data are expressed as means ± SE. * P<0.05 vs. CD; # p<0.05 vs WD.