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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Metabolism. 2017 Jun 21;74:32–40. doi: 10.1016/j.metabol.2017.06.006

Figure 3. XO inhibition suppresses WD-induced inflammatory gene expression in aorta.

Figure 3

A. mRNA expression of MCP-1, a marker of EC activation, is increased in WD-fed mice which was prevented by XO inhibition B. CD11b as indicator of macrophage recruitment is increased in WD-fed group but not in WD plus XO inhibitor group. C. CD 86 expression is increased in WD-fed mice indicating M1 polarization and this response was blunted by XO inhibition. D. IL-6 expression is a marker of M1 polarization and enhanced pro-inflammatory response to WD feeding. This response is prevented by XO inhibitor treatment in WD-fed mice. N = 3 per group. CD - control diet, WD - Western Diet, WDA - Western diet plus allopurinol. Data are expressed as means ± SE. * P<0.05 vs CD; # p<0.05 vs WD.