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. 2017 Aug 30;17:601. doi: 10.1186/s12885-017-3582-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Methylation levels of LINE-1 in cases (CIN2+) and controls (≤CIN1). Mean methylation levels of LINE-1 sequences (mean percentage of methylation of the three evaluated CpG sites) in CIN2+ patients (cases) and in CIN 1 or normal cervical epithelium patients (controls) obtained using pyrosequencing of bisulfite converted DNA from WBCs (p-value = 0.002, based on the Mann-Whitney U test)