Figure 3.
Effect of inactivating OFC→BLA or BLA→OFC projections on PIT. A, Task design. O, Outcome/reward; A, action. B, C, Trial-averaged lever presses per 2-min period averaged across both levers during the Baseline periods compared with pressing during the CS periods separated for presses on the lever that, in training, delivered the same outcome as predicted by the CS (CS-Same) and pressing on the other available lever (CS-Diff) for OFChM4Di→BLA (B; n = 10) or BLAhM4Di→OFC (C; n = 10) groups. Inset, CS-induced elevation in responding [CS presses/(CS presses + Baseline presses)] on action Same versus Different for the BLAhM4Di→OFC group. D, E, Trial-averaged entries into the food-delivery port during the Baseline and CS periods for the OFChM4Di→BLA (D) and BLAhM4Di→OFC (E) groups. Error bars indicate SEM. *p < 0.05. **p < 0.01. ***p < 0.001.