Figure 12.
Synaptic markers are present in the retinas of dystroglycan mutants. A, Markers for outer retinal ribbon synapses (Ribeye, presynaptic and mGluR6, postsynaptic) appear structurally normal in the absence of dystroglycan. The density of excitatory (VGLUT1) (B) and inhibitory (VGAT) (C) presynaptic markers appear similar to control in the inner retinas of DGF/−;Six3Cre mutants. Synapses are also present within ectopic clusters (asterisks). Scale bar, 50 μm wide view; 10 μm enlarged view.