Figure 13.
Dystroglycan is dispensable for the generation and propagation of retinal waves. A, B, At P1, waves propagate normally across the retina in DGF/+;Six3Cre;R26-LSL-GCaMP6f (A) and DGF/−;Six3Cre;R26-LSL-GCaMP6f mice (B). C, Distributions of wave areas show no difference between controls and mutants (Wilcoxon rank-sum test, p > 0.05). D, Wave propagation rate is slightly slower in mutant retinas (Wilcoxon rank-sum test, p = 0.0493). Wave parameters were calculated from 142 control waves obtained from six retinas from three control mice and 173 mutant waves obtained from eight retinas from five mutant mice. Arrowheads indicate the initiation site of a retinal wave. Scale bar, 500 μm. Time is displayed in milliseconds.